Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography
نویسندگان
چکیده
منابع مشابه
ABL gene kinase domain mutation scanning by denaturing high performance liquid chromatography sequencing method.
OBJECTIVE Despite the efficacy of the BCR-ABL tyrosine kinase inhibitor imatinib, the development of resistance against imatinib has been observed. The most important mechanisms known to cause resistance are point mutations in the ABL tyrosine kinase and the ATP domain. This study describes the use of denaturing high performance liquid chromatography (dHPLC) as a method to screen for mutations ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2004
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2403307